Magnesium-mediated intramolecular reductive coupling: a stereoselective synthesis of C(2)-symmetric 3,4-bis-silyl-substituted adipic acid derivatives.
نویسندگان
چکیده
Chiral C(2)-symmetric 3,4-bis-silyl-substituted adipic acid derivatives have been synthesised by a Mg/trimethylsilyl chloride-mediated intramolecular reductive coupling of symmetrical disiloxanes of beta-silylacrylic acid N-oxazolidinone derivatives. Efficient and short syntheses of enantiomerically pure enantiomers of 2,6-dioxabicyclo[3.3.0]octane-3,7-dione have been achieved from the bis-silylated adipic acid derivatives using Fleming-Tamao oxidation as the key step.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 22 شماره
صفحات -
تاریخ انتشار 2009